@article{8764, keywords = {Humans, Leprostatic Agents, leprosy}, author = {Worobec SM}, title = {Treatment of leprosy/Hansen's disease in the early 21st century.}, abstract = {
Leprosy, or Hansen's disease (HD), is caused by Mycobacterium leprae, a slowly dividing mycobacterium that has evolved to be an intracellular parasite, causing skin lesions and nerve damage. Less than 5% of people exposed to M. leprae develop clinical disease. Host cell-mediated resistance determines whether an individual will develop paucibacillary or multibacillary disease. Hansen's disease is a worldwide disease with about 150 new cases reported annually in the United States. Effective anti-mycobacterial treatments are available, and many patients experience severe reversal and erythema nodosum leprosum reactions that also require treatment. Leprosy has been the target of a World Health Organization multiple drug therapy campaign to eliminate it as a national public health problem in member countries, but endemic regions persist. In the United States, the National Hansen's Disease Program has primary responsibility for medical care, research, and information.
}, year = {2009}, journal = {Dermatologic therapy}, volume = {22}, pages = {518-37}, month = {2009 Nov-Dec}, issn = {1529-8019}, doi = {10.1111/j.1529-8019.2009.01274.x}, language = {eng}, }