@article{8748,
  keywords = {Animals, Bacterial Proteins, DNA, Bacterial, Genetic Variation, leprosy, Minisatellite Repeats, Mycobacterium leprae, Polymorphism, Single Nucleotide, Sigma Factor},
  author = {Matsuoka M and Gonzalez AV and Estrada I and Carreño-Martinez C and Fafutis-Morris M},
  title = {Various genotypes of Mycobacterium leprae from Mexico reveal distinct geographic distribution.},
  abstract = {<p><b>OBJECTIVE: </b>To classify Mycobacterium leprae isolates from multiple areas in Mexico based on variable number of tandem repeats of 6 base within the rpoT gene and three single nucleotide polymorphism (SNP), and to analyse their geographic distribution in the context of the origin of leprosy in Mexico.</p><p><b>RESULTS: </b>Analysis for rpoT genotyping of 64 samples collected in the west and southwestern areas revealed that 46 isolates were of the 4 copy type and 18 isolates were of the 3 copy type. All samples from the eastern coastal area (n = 24) and from the Yucatan peninsula (n = 12) were of the 3 copy type. Six isolates from the west and southwestern area were SNP-type 1, 13 isolates were SNP-type 2 and 45 isolates were SNP-type 3. Nineteen of 24 isolates from the eastern coastal area were SNP-type 3 and one was SNP-type 4. Seven isolates from the Yucatan peninsula were SNP-type 3 and one was SNP-type 4.</p><p><b>CONCLUSION: </b>The difference of the proportion of each genotype between the western areas and the eastern areas indicated the expansion of leprosy through different paths in Mexico.</p>},
  year = {2009},
  journal = {Leprosy review},
  volume = {80},
  pages = {322-6},
  month = {2009 Sep},
  issn = {0305-7518},
  url = {https://leprosyreview.org/article/80/3/32-2326},
  doi = {10.2165/11310740-000000000-00000},
  language = {eng},
}