@article{8611,
  keywords = {Chromosome Mapping, DNA Primers, Exons, Genes, Dominant, Genes, Recessive, Haplotypes, Humans, Lectins, leprosy, Polymorphism, Genetic, Promoter Regions, Genetic, Reference Values},
  author = {Messias-Reason LJT and Kremsner PG and Kun JF J},
  title = {Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy.},
  abstract = {<p>Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the promoter and exon 8 of FCN2 were assessed by DNA sequencing. The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae.</p>},
  year = {2009},
  journal = {The Journal of infectious diseases},
  volume = {199},
  pages = {801-4},
  month = {2009 Mar 15},
  issn = {0022-1899},
  doi = {10.1086/597070},
  language = {eng},
}