@article{8534,
  keywords = {Base Sequence, Cytokines, Humans, Immunity, Innate, Interferon-gamma, Interleukin-10, Interleukin-2, Interleukin-4, Interleukin-5, leprosy, Molecular Sequence Data, polymerase chain reaction, RNA, Messenger, Skin},
  author = {Yamamura M and Uyemura K and Deans R J and Weinberg K and Rea T H and Bloom B R and Modlin R L},
  title = {Defining protective responses to pathogens: cytokine profiles in leprosy lesions.},
  abstract = {<p>The immunological mechanisms required to engender resistance have been defined in few infectious diseases of man, and the role of specific cytokines is unclear. Leprosy presents clinically as a spectrum in which resistance correlates with cell-mediated immunity to the pathogen. To assess in situ cytokine patterns, messenger RNA extracted from leprosy skin biopsy specimens was amplified by the polymerase chain reaction with 14 cytokine-specific primers. In lesions of the resistant form of the disease, messenger RNAs coding for interleukin-2 and interferon-gamma were most evident. In contrast, messenger RNAs for interleukin-4, interleukin-5, and interleukin-10 predominated in the multibacillary form. Thus, resistance and susceptibility were correlated with distinct patterns of cytokine production.</p>},
  year = {1991},
  journal = {Science (New York, N.Y.)},
  volume = {254},
  pages = {277-9},
  month = {1991 Oct 11},
  issn = {0036-8075},
  doi = {10.1126/science.1925582},
  language = {eng},
}