@article{8432,
  keywords = {Antigens, Bacterial, Disease Susceptibility, Genes, MHC Class II, Genetic Markers, HLA Antigens, Humans, leprosy, Leprosy, lepromatous, Leprosy, Tuberculoid, Mycobacterium leprae, T-Lymphocytes},
  author = {Vries R R},
  title = {Genetic control of immunopathology induced by Mycobacterium leprae.},
  abstract = {<p>The pathogenesis of leprosy is almost totally attributable to the immune response of the host towards Mycobacterium leprae, a virtually non-toxic intra-cellular parasite. At one end of the leprosy spectrum are tuberculoid leprosy patients, who develop immunity but also delayed-type hypersensitivity towards M. leprae; at the other end are lepromatous leprosy patients, who lack helper T cell activity and therefore do not develop immunity, but who can nevertheless produce antibodies that may cause immunopathology due to immune complexes. A range of immunopathology is seen between these poles.</p>},
  year = {1991},
  journal = {The American journal of tropical medicine and hygiene},
  volume = {44},
  pages = {12-6},
  month = {1991 Apr},
  issn = {0002-9637},
  doi = {10.4269/ajtmh.1991.44.12},
  language = {eng},
}