@article{8405,
  keywords = {CD4-Positive T-Lymphocytes, Cells, Cultured, Child, Preschool, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Infant, Infant, Newborn, Interleukin-10, Lymphocyte Activation, Macrophages, Membrane Proteins, Mycobacterium bovis},
  author = {Makino M and Maeda Y and Kai M and Tamura T and Mukai T},
  title = {GM-CSF-mediated T-cell activation by macrophages infected with recombinant BCG that secretes major membrane protein-II of Mycobacterium leprae.},
  abstract = {<p>The potential of Mycobacterium bovis Bacillus Calmette-Guerin (BCG) needs to be augmented to efficiently activate CD4(+) T cells through macrophages. Mycobacterium leprae-derived recombinant major membrane protein (MMP)-II induced GM-CSF production from macrophages. A recombinant BCG-SM that secretes MMP-II more efficiently produced GM-CSF and activated interferon (IFN)-gamma-producing CD4(+) T cells than did vector control BCG when infected with macrophages. The T-cell activation by BCG-SM was dependent on the GM-CSF production by macrophages. Interleukin (IL)-10 production by macrophages stimulated with M. leprae was inhibited in a GM-CSF-dependent manner when the precursor monocytes were infected with BCG-SM. BCG inducing GM-CSF production was effective in macrophage-mediated T-cell activation partially through IL-10 inhibition.</p>},
  year = {2009},
  journal = {FEMS immunology and medical microbiology},
  volume = {55},
  pages = {39-46},
  month = {2009 Jan},
  issn = {1574-695X},
  doi = {10.1111/j.1574-695X.2008.00495.x},
  language = {eng},
}