@article{8364,
  keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Exons, Female, Gene Frequency, Genetic Predisposition to Disease, genotype, Humans, Leprosy, lepromatous, Male, Mexico, Middle Aged, Polymorphism, Restriction Fragment Length, Receptors, Calcitriol, Taq Polymerase, Young Adult},
  author = {Velarde Félix JS and Cázarez Salazar SG and Castro Velázquez R and Rendón Maldonado JG and Rangel Villalobos H},
  title = {[Association between the TaqI polymorphism of the vitamin D receptor gene and lepromatous leprosy in a Mexican population sample].},
  abstract = {<p><b>OBJECTIVE: </b>To establish the association of the vitamin D receptor gene TaqI polymorphism with lepromatous leprosy (LL) in individuals from Sinaloa, Mexico.</p><p><b>MATERIAL AND METHODS: </b>A 740 bp fragment was amplified from the VDR gene in DNA samples of 71 patients with LL and 144 controls in the Hospital General de Culiacán during 2004-2007. Polymorphism was identified through TaqI endonuclease.</p><p><b>RESULTS: </b>A significant increase in the genotype TT of the VDR gene was observed in patients when compared to controls (p = 0.040; OR = 1.82).</p><p><b>CONCLUSIONS: </b>Our data support the association between the TT genotype and susceptibility to LL in this Mexican population.</p>},
  year = {2009},
  journal = {Salud publica de Mexico},
  volume = {51},
  pages = {59-61},
  month = {2009 Jan-Feb},
  issn = {1606-7916},
  doi = {10.1590/s0036-36342009000100011},
  language = {spa},
}