@article{8352,
  keywords = {Administration, Oral, Animals, Anti-Bacterial Agents, Colony Count, Microbial, Drug Resistance, Bacterial, Female, Fluoroquinolones, leprosy, Mice, Mice, Inbred BALB C, Mice, Nude, Mycobacterium leprae, Structure-Activity Relationship},
  author = {Gidoh M},
  title = {[Structure and anti-M. leprae activity relationships of new quinolones].},
  abstract = {<p>Due to the emergence of drug resistant M. leprae, there is a need to look for new drugs for the treatment of leprosy. We evaluated the effectiveness of new quinolones in vitro as well as in vivo. The in vitro and in vivo results suggested that a cyclopropyl group at the 1-position, COOH at the 3-position, OH at the 4-position, NH2 or OH-substitutions at the 5-position, F at the 6-position, 5- and 6-membered rings at the 7-position, halogen (F or Cl) or OCH3 at the 8-position of the quinolone core structure remarkably enhance anti-M. leprae activities of the drug.</p>},
  year = {2009},
  journal = {Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association},
  volume = {78},
  pages = {17-23},
  month = {2009 Feb},
  issn = {1342-3681},
  language = {jpn},
}