@article{8196, keywords = {Animals, Humans, Interleukins, leprosy, Macrophages, Receptors, Antigen, T-Cell, T-Lymphocyte Subsets, Tuberculosis}, author = {Kaufmann S H}, title = {The macrophage in tuberculosis: sinner or saint? The T cell decides.}, abstract = {
Immunity to intracellular bacteria including Mycobacterium tuberculosis crucially depends on intricate interactions between T lymphocytes and macrophages. Before contact with T lymphocytes macrophages serve as habitat for M. tuberculosis organisms; after activation by T cells they become major effectors against these pathogens. T cells comprise different subsets which express different functional activities. This paper describes evidence that different T cell subsets (CD4 alpha/beta T cells, CD8 alpha/beta T cells and gamma/delta T cells) as well as different T cell functions (interleukin secretion and target cell lysis) contribute to immunity against tuberculosis.
}, year = {1991}, journal = {Pathobiology : journal of immunopathology, molecular and cellular biology}, volume = {59}, pages = {153-5}, month = {1991}, issn = {1015-2008}, doi = {10.1159/000163634}, language = {eng}, }