@article{8183,
  keywords = {Adult, Aged, Cohort Studies, Female, Humans, Leprostatic Agents, leprosy, Male, Middle Aged, Retrospective Studies, Travel, United States},
  author = {Jacob JT and Kozarsky P and Dismukes R and Bynoe V and Margoles L and Leonard M and Tellez I and Franco-Paredes C},
  title = {Five-year experience with type 1 and type 2 reactions in Hansen disease at a US travel clinic.},
  abstract = {<p>Very few data have been reported on the epidemiology and clinical features of leprosy reactions in non-endemic settings. We performed a retrospective descriptive analysis to define the frequency and features of Type 1 and Type 2 leprosy reactions in a cohort of patients followed at a US travel and tropical medicine clinic in a 5-year period. We identified that leprosy reactions presented in 10/14 (71.4%) patients with leprosy seen at our clinic. We identified that leprosy reactions occur frequently among patients living in non-endemic areas and may occur before the initiation of multi-drug therapy (MDT), during MDT, or even years after completion of therapy and may produce significant neurologic sequelae. This group of patients needs long-term clinical monitoring even after completion of MDT because of the need to continue either anti-inflammatory therapy, presence of severe neurologic sequelae after reactions, or the potential occurrence of late leprosy reactions.</p>},
  year = {2008},
  journal = {The American journal of tropical medicine and hygiene},
  volume = {79},
  pages = {452-4},
  month = {2008 Sep},
  issn = {1476-1645},
  url = {http://www.ajtmh.org/content/79/3/452.full.pdf+html},
  language = {eng},
}