@article{8174,
  keywords = {Animals, Bacterial Proteins, Drug Resistance, Bacterial, Female, Humans, Japan, Leprostatic Agents, leprosy, Male, Mice, Mutation, Mycobacterium leprae, polymerase chain reaction},
  author = {Ozaki M},
  title = {[Drug resistance of multibacillary leprosy patients in Japan--results of molecular genetic analyses].},
  abstract = {<p><b>UNLABELLED: </b>Gene mutation of Mycobacterium leprae was studied on bacilli-positive multibacillary leprosy patients since 2000 in Japan.</p><p><b>SUBJECTS: </b>LL 31 cases, BL 7 cases.</p><p><b>RESULTS: </b>gene mutation of folP was found in 19/36 cases (52.8%), that of rpoB in 13/33 cases (39.4%), that of gyrA in 6/31 cases (16.8%). Five cases showed both mutations of folP and rpoB, and one case showed those of fol/P and gyrA. Mutations of folP, rpoB andgyrA all were found in 4/36 cases (10.3%). High incidence of resistance to DDS or rifampicin was observed, and incidence of resistance to of loxacin was considerably high. These results reveal existence of multidrug-resistant bacilli in Japanese leprosy patients. Treatment of these cases was arranged according to the result of gene mutation analysis and satisfactory effects were obtained in 34/38 cases. One case did not response to newer treatment. Three cases refused use of improved treatment and their disease activities are not controlled. This study proved that gene mutation analysis is a rapid and accurate method to know the drug resistance against DDS, rifampicin and new quinolones, and important in chemotherapy of leprosy.</p>},
  year = {2008},
  journal = {Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association},
  volume = {77},
  pages = {187-96},
  month = {2008 Sep},
  issn = {1342-3681},
  language = {jpn},
}