@article{8147,
  keywords = {Animals, Armadillos, Benzylamines, Dapsone, Leprostatic Agents, leprosy, Mice, Mice, Inbred BALB C, Microbial Sensitivity Tests, Mycobacterium leprae, Rifampin},
  author = {Dhople A M and Strong L C and Meindl W and Schoenenberger H and Gardner G D},
  title = {In vitro and in vivo effects of N-methyl-3,5-dichloro-benzylamine hydrochloride on Mycobacterium leprae.},
  abstract = {<p>The antimicrobial effects of a new benzylamine, ME-93 (N-methyl-3,5-dichloro-benzylamine hydrochloride), alone and in combination with dapsone and rifampicin, have been evaluated in vitro in cell-free culture system and in vivo in mouse foot pad system. Even at 50 micrograms/ml, ME-93 did not completely inhibit the in vitro growth of M. leprae, and the effects were bacteriostatic. However, there was a synergism when ME-93 was combined with rifampicin, and the effects were bactericidal. Similar findings were also obtained in the mouse foot pad system. Thus, there is a new drug that needs further attention in the chemotherapy of leprosy.</p>},
  year = {1991},
  journal = {Arzneimittel-Forschung},
  volume = {41},
  pages = {253-6},
  month = {1991 Mar},
  issn = {0004-4172},
  language = {eng},
}