@article{8132,
  keywords = {Adolescent, Adult, Anti-Inflammatory Agents, Female, Humans, Leprosy, Borderline, Leprosy, Tuberculoid, Male, Middle Aged, Skin, Time Factors},
  author = {Saxena U and Ramesh V and Misra R S and Mukherjee A},
  title = {Persistent reaction in paucibacillary leprosy: case reports.},
  abstract = {<p>Three patients of histopathologically confirmed borderline-tuberculoid leprosy showing no acid-fast bacilli and with lesions confined to the face, 2 on the cheek and 1 on the forehead, were given multidrug therapy as recommended by the WHO for paucibacillary cases. Within 3 months the lesions showed signs of upgrading (or reversal) reaction which was substantiated by histopathology. In 1 patient the facial nerve was affected leading to facial palsy. The lymphocyte transformation test did not show a significant rise. All 3 patients were given oral prednisolone for periods varying between 5 and 7 months, but the response was poor except in 1 patient in whom the facial palsy responded favourably. Injections of sodium antimony gluconate tried in 1 patient after stoppage of steroids did not control the reaction. After 18 months of regular follow-up during therapy, the cutaneous reaction in the patient with facial nerve involvement subsided leaving significant atrophy. However, in the other 2 patients the skin lesion persisted with clinical and histopathological evidence of upgrading reaction. The reasons for the unnatural persistence of reaction in these patients is not clear.</p>},
  year = {1991},
  journal = {Leprosy review},
  volume = {62},
  pages = {206-11},
  month = {1991 Jun},
  issn = {0305-7518},
  url = {http://leprev.ilsl.br/pdfs/1991/v62n2/pdf/v62n2a13.pdf},
  doi = {10.5935/0305-7518.19910025},
  language = {eng},
}