@article{7903,
  keywords = {Adolescent, Adult, Antioxidants, Child, Child, Preschool, Humans, leprosy, Lipid Peroxidation, Malondialdehyde, Middle Aged, Oxidative Stress, Skin, Superoxide Dismutase},
  author = {Jyothi P and Riyaz N and Nandakumar G and Binitha M P},
  title = {A study of oxidative stress in paucibacillary and multibacillary leprosy.},
  abstract = {<p><b>BACKGROUND: </b>The study and assessment of oxidative stress plays a significant role in the arena of leprosy treatment. Once the presence of oxidative stress is proved, antioxidant supplements can be provided to reduce tissue injury and deformity.</p><p><b>AIM: </b>To study oxidative stress in paucibacillary (PB) and multibacillary (MB) leprosy and to compare it with that in a control group.</p><p><b>METHODS: </b>Fifty-eight untreated leprosy patients (23 PB and 35 MB cases) were studied and compared with 58 healthy controls. Superoxide dismutase (SOD) level as a measure of antioxidant status; malondialdehyde (MDA)level, an indicator of lipid peroxidation; and MDA/SOD ratio, an index of oxidative stress were estimated in the serum.</p><p><b>RESULTS: </b>The SOD level was decreased in leprosy patients, especially in MB leprosy. The MDA level was increased in PB and MB leprosy. The MDA/SOD ratio was significantly elevated in MB patients. There was a steady increase in this ratio along the spectrum from tuberculoid to lepromatous leprosy (LL).</p><p><b>CONCLUSION: </b>There is increased oxidative stress in MB leprosy, especially in LL. This warrants antioxidant supplements to prevent tissue injury.</p>},
  year = {2008},
  journal = {Indian journal of dermatology, venereology and leprology},
  volume = {74},
  pages = {80},
  month = {2008 Jan-Feb},
  issn = {0973-3922},
  url = {http://www.ijdvl.com/text.asp?2008/74/1/80/38428},
  language = {eng},
}