@article{7755,
  keywords = {Angiogenesis Inhibitors, Blood Vessels, Humans, Immunohistochemistry, leprosy, Leprosy, Borderline, Leprosy, lepromatous, Leprosy, Tuberculoid, Microcirculation, Neovascularization, Pathologic, Platelet Endothelial Cell Adhesion Molecule-1, Skin},
  author = {Bhandarkar SS and Cohen C and Kuruvila M and Rea T and Mackelfresh JB and Lee DJ and Modlin RL and Arbiser J},
  title = {Angiogenesis in cutaneous lesions of leprosy: implications for treatment.},
  abstract = {<p><b>OBJECTIVE: </b>To examine the potential role of angiogenesis in leprosy.</p><p><b>DESIGN: </b>Immunohistochemical analysis of leprosy lesions.</p><p><b>SETTING: </b>Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University.</p><p><b>PATIENTS: </b>Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients.</p><p><b>MAIN OUTCOME MEASURE: </b>CD31 microvessel counts.</p><p><b>RESULTS: </b>The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions.</p><p><b>CONCLUSIONS: </b>Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.</p>},
  year = {2007},
  journal = {Archives of dermatology},
  volume = {143},
  pages = {1527-9},
  month = {2007 Dec},
  issn = {1538-3652},
  doi = {10.1001/archderm.143.12.1527},
  language = {eng},
}