@article{772,
  keywords = {Adolescent, Adult, Aged, Clofazimine, Dapsone, Drug Therapy, Combination, Female, Humans, Leprostatic Agents, leprosy, Male, Middle Aged, Nepal, Retrospective Studies, Rifampin, Treatment Outcome},
  author = {Sapkota BR and Shrestha K and Pandey B and Walker SL},
  title = {A retrospective study of the effect of modified multi-drug therapy in Nepali leprosy patients following the development of adverse effects due to dapsone.},
  abstract = {<p><b>INTRODUCTION: </b>Dapsone Hypersensitivity Syndrome (DHS) occurs in approximately 2% of leprosy patients in Nepal. DHS and other adverse effects of dapsone lead to withdrawal of the drug.</p><p><b>METHODS: </b>We reviewed the notes of patients who had dapsone withdrawn from their multi-drug therapy (MDT) following an adverse reaction to the drug between 1990 and 2007.</p><p><b>RESULTS: </b>105 patients were identified from the database and 67 had a documented completion of a modified course of MDT. The majority were treated with rifampicin and clofazimine. All 36 individuals who were slit-skin smear positive had a satisfactory fall in their mean bacterial index. There were no cases of relapse.</p><p><b>CONCLUSIONS: </b>Rifampicin and clofazimine appear to be satisfactory treatment for both paucibacillary and multibacillary patients who have to have dapsone stopped because of severe adverse effects.</p>},
  year = {2008},
  journal = {Leprosy review},
  volume = {79},
  pages = {425-8},
  month = {2008 Dec},
  issn = {0305-7518},
  url = {https://leprosyreview.org/article/79/4/42-5428},
  language = {eng},
}