@article{7491,
  keywords = {Antibodies, Bacterial, Enzyme-Linked Immunosorbent Assay, Humans, Japan, leprosy, Membrane Proteins, Mycobacterium leprae, Sensitivity and Specificity, Serologic Tests},
  author = {Maeda Y and Mukai T and Kai M and Fukutomi Y and Nomaguchi H and Abe C and Kobayashi K and Kitada S and Maekura R and Yano I and Ishii N and Mori T and Makino M},
  title = {Evaluation of major membrane protein-II as a tool for serodiagnosis of leprosy.},
  abstract = {<p>As serodiagnosis is the easiest way of diagnosing a disease, the utility of Mycobacterium leprae-derived major membrane protein-II (MMP-II), one of the immuno-dominant antigens, in the serodiagnosis of leprosy was examined. The percent positivity by an enzyme-linked immunosorbent assay for anti-MMP-II antibody was 82.4% for multi-bacillary leprosy, and the specificity of the test was 90.1%. For pauci-bacillary leprosy where cell-mediated immunity predominates, 39.0% showed positive results. These percentage values were significantly higher than these values obtained for existing phenolic glycolipid-I based methods, suggesting that MMP-II antibody detection would facilitate the diagnosis of leprosy.</p>},
  year = {2007},
  journal = {FEMS microbiology letters},
  volume = {272},
  pages = {202-5},
  month = {2007 Jul},
  issn = {0378-1097},
  url = {http://onlinelibrary.wiley.com/doi/10.1111/j.1574-6968.2007.00754.x/pdf},
  doi = {10.1111/j.1574-6968.2007.00754.x},
  language = {eng},
}