@article{7459,
  keywords = {Alleles, Case-Control Studies, Cation Transport Proteins, Disease Susceptibility, genotype, Humans, leprosy, Polymorphism, Genetic, Risk Factors, Thailand, Tumor Necrosis Factor-alpha},
  author = {Vejbaesya S and Mahaisavariya P and Luangtrakool P and Sermduangprateep C},
  title = {TNF alpha and NRAMP1 polymorphisms in leprosy.},
  abstract = {<p><b>OBJECTIVE: </b>To determine the association of TNF alpha and NRAMP1 polymorphisms in leprosy.</p><p><b>MATERIAL AND METHOD: </b>The polymorphisms of TNF alpha at -238, -308, and NRAMP1 at INT4, D543N, and3' UTR were examined in 37 patients with leprosy (24 multibacillary and 13 paucibacillary) and 140 healthy controls. PCR-SSP and PCR-SSO method were used to type TNF and NRAMP1 polymorphisms.</p><p><b>RESULTS: </b>The genotype frequency of TNF-308 G/A was significantly increased in all leprosy patients compared to the controls (p = 0.04, OR = 2.69). When leprosy types were divided, the allele frequency of TNF-308A was significantly increased in multibacillary leprosy compared to the normal controls (p = 0.04, OR = 2.93). There was no significant difference in the distribution of the genotypes and allele frequencies of TNF -238 and NRAMP1 polymorphisms between the patients and controls.</p><p><b>CONCLUSION: </b>TNF-308A was associated with susceptibility to multibacillary leprosy.</p>},
  year = {2007},
  journal = {Journal of the Medical Association of Thailand = Chotmaihet thangphaet},
  volume = {90},
  pages = {1188-92},
  month = {2007 Jun},
  issn = {0125-2208},
  language = {eng},
}