@article{7283,
  keywords = {Antigens, Bacterial, Base Sequence, CD4-Positive T-Lymphocytes, Cells, Cultured, Clone Cells, Complementarity Determining Regions, HLA-DR Antigens, Histocompatibility Testing, Humans, Interferon-gamma, leprosy, Male, Molecular Sequence Data, Mycobacterium leprae, Receptors, Antigen, T-Cell, alpha-beta, Reverse Transcriptase Polymerase Chain Reaction},
  author = {Sabet S and Ochoa M and Sieling PA and Rea T and Modlin RL},
  title = {Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion.},
  abstract = {<p>Human infection with Mycobacterium leprae, an intracellular bacterium, presents as a clinical and immunological spectrum; thus leprosy provides an opportunity to investigate mechanisms of T-cell responsiveness to a microbial pathogen. Analysis of the T-cell receptor (TCR) repertoire in leprosy lesions revealed that TCR BV6(+) T cells containing a conserved CDR3 motif are over-represented in lesions from patients with the localized form of the disease. Here, we derived a T-cell clone from a leprosy lesion that expressed TCR BV6 and the conserved CDR3 sequence L-S-G. This T-cell clone produced a T helper type 1 cytokine pattern, directly lysed M. leprae-pulsed antigen-presenting cells by the granule exocytosis pathway, and expressed the antimicrobial protein granulysin. BV6(+) T cells may therefore functionally contribute to the cell-mediated immune response against M. leprae.</p>},
  year = {2007},
  journal = {Immunology},
  volume = {120},
  pages = {354-61},
  month = {2007 Mar},
  issn = {0019-2805},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265884/pdf/imm0120-0354.pdf},
  doi = {10.1111/j.1365-2567.2006.02510.x},
  language = {eng},
}