@article{7224,
  keywords = {Antigens, Differentiation, T-Lymphocyte, Candidiasis, Chronic Mucocutaneous, Candidiasis, Oral, CD2 Antigens, CD3 Complex, Disease Susceptibility, Female, Genetic Predisposition to Disease, Humans, Immunocompromised Host, Immunologic Deficiency Syndromes, Infant, Lymphocyte Activation, Opportunistic Infections, Receptors, Immunologic, T-Lymphocyte Subsets, Toxoplasmosis, Tuberculosis},
  author = {Noh L M and Hussein S H and Sukumaran K D and Rose I and Abdullah N},
  title = {Chronic mucocutaneous candidiasis with deficient CD2 (E receptor) but normal CD3 mononuclear cells.},
  abstract = {<p>A case of chronic mucocutaneous candidiasis in a Malaysian child who subsequently developed disseminated tuberculosis and toxoplasmosis is described. The phenotype of her peripheral blood mononuclear cells showed discordance for her T cell markers. The presence of a subpopulation of CD2-/CD3+ mononuclear cells leading to an immunodeficiency state is consistent with failure of activation of CD2-mediated alternative pathway resulting in immunodeficiency. Such abnormal CD2-/CD3+ subpopulations have been described in lepromatous leprosy and foetal abortuses.</p>},
  year = {1991},
  journal = {Journal of clinical & laboratory immunology},
  volume = {35},
  pages = {89-93},
  month = {1991 Jun},
  issn = {0141-2760},
  language = {eng},
}