@article{719,
  keywords = {Alleles, Antigens, Bacterial, Genetic Predisposition to Disease, Histocompatibility Testing, HLA-DQ Antigens, HLA-DR Antigens, Humans, Immunity, Innate, Indonesia, leprosy, Leprosy, Borderline, Leprosy, lepromatous, Leprosy, Tuberculoid, Mycobacterium leprae, Odds Ratio, polymerase chain reaction, Sequence Analysis, DNA},
  author = {Soebono H and Giphart M J and Schreuder G M and Klatser P R and Vries R R},
  title = {Associations between HLA-DRB1 alleles and leprosy in an Indonesian population.},
  abstract = {<p>To investigate whether the susceptibility to leprosy (type), subclinical infection with Mycobacterium leprae and the antibody response against M. leprae-specific antigens are associated with HLA-DR phenotypes sequence-specific oligonucleotide HLA-DRB1 and DQA1 typing and antibody assays have been performed in 79 leprosy patients (41 TT/BT and 38 LL/BL) and 50 healthy controls from a Javanese population in Yogyakarta, Indonesia. DRB1*02 was associated with LL/BL [odds ratio (OR) 2.54, 95% confidence interval (CI) 0.97-9.78, p = 0.037 and attributable risk (AR) 41.5%] but not with TT/BT leprosy (p > 0.05). HLA-DRB1*12 was negatively associated with leprosy (either LL/BL or TT/BT [OR 0.33-0.35, p < 0.05, prevented fraction (PF) 58.8%-65.3%]. No significant association was found between HLA-DRB1 or DQA1 type, anti-M. leprae antibody level and subclinical infection with M. leprae. These data indicate that in this population susceptibility to lepromatous leprosy is associated with HLA-DRB1*02, while resistance to leprosy is associated with HLA-DRB1*12. These associations are not paralleled with associations of the same HLA types with anti-M. leprae antibody level. Finally, the results of this study also support the notion that infection with M. leprae per se is not associated with HLA-DRB1 or DQA1 alleles.</p>},
  year = {1997},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {65},
  pages = {190-6},
  month = {1997 Jun},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v65n2a05.pdf},
  language = {eng},
}