@article{7152,
  keywords = {Animals, Clofazimine, Culture Media, Dapsone, Drug Interactions, Drug Therapy, Combination, Leprostatic Agents, leprosy, Mice, Microbial Sensitivity Tests, Mycobacterium leprae, Rifabutin, Rifampin, Rifamycins},
  author = {Dhople A M and Lamoureux L C and Gardner G D},
  title = {In vitro and in vivo interactions of drugs used in multidrug therapy in leprosy.},
  abstract = {<p>Interactions of different drugs commonly used in multiple drug therapy were evaluated using both in vitro culture (cell-free as well as macrophage) system and mouse footpad. No additive effects were obtained in the in vitro system when dapsone was combined with either rifampicin or clofazimine, while a strong antagonism was observed when clofazimine was combined with rifampicin but not with rifabutin. In the mouse footpad system, a strong synergism was obtained when clofazimine was combined with either rifampicin or rifabutin, but significant antagonism was observed with the combination of clofazimine and dapsone.</p>},
  year = {1991},
  journal = {Indian journal of leprosy},
  volume = {63},
  pages = {166-79},
  month = {1991 Apr-Jun},
  issn = {0254-9395},
  language = {eng},
}