@article{7143,
  keywords = {Antibody Formation, CD4 Antigens, CD4-Positive T-Lymphocytes, CD8 Antigens, Clone Cells, Humans, Interferon-gamma, Interleukin-4, Interleukins, leprosy, Lymphokines, T-Lymphocyte Subsets, T-Lymphocytes},
  author = {Salgame P and Abrams J S and Clayberger C and Goldstein H and Convit J and Modlin R L and Bloom B R},
  title = {Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones.},
  abstract = {<p>Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-gamma, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-gamma. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.</p>},
  year = {1991},
  journal = {Science (New York, N.Y.)},
  volume = {254},
  pages = {279-82},
  month = {1991 Oct 11},
  issn = {0036-8075},
  doi = {10.1126/science.1681588},
  language = {eng},
}