@article{7140,
  keywords = {Animals, Anti-Infective Agents, Ciprofloxacin, Fleroxacin, Fluoroquinolones, leprosy, Mice, Mycobacterium leprae, Quinolones},
  author = {Pattyn S R},
  title = {Anti-Mycobacterium leprae activity of several quinolones studied in the mouse.},
  abstract = {<p>The anti-Mycobacterium leprae activity of several fluoroquinolones (A-56619, A-56620, ofloxacin, fleroxacin, lomefloxacin, temafloxacin, tosufloxacin, and PD-117596) was studied in the mouse. In a dosage of 150 mg/kg administered daily, A-56619 is active and A-56620 is inactive against M. leprae. Ofloxacin administered daily for 2 weeks at 300 mg/kg is bactericidal. The minimal effective dose of PD-117596, lomefloxacin and temafloxacin is less than 37.5 mg/kg. When administered at 300 mg/kg at monthly intervals temafloxacin, PD-117596, and ofloxacin are bacteriostatic; while fleroxacin and lomefloxacin are bactericidal. Tosufloxacin is less active than the other quinolones included in the present study.</p>
},
  year = {1991},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {59},
  pages = {613-7},
  month = {1991 Dec},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v59n4a10.pdf},
  language = {eng},
}