@article{6973,
  keywords = {Adult, Antigens, Bacterial, Cell Adhesion Molecules, Cell Line, Culture Media, Female, HIV Seronegativity, HIV Seropositivity, Humans, Lectins, C-Type, leprosy, Leprosy, Borderline, Leprosy, Tuberculoid, Lipopolysaccharides, Macrophages, Male, Middle Aged, Mycobacterium leprae, Mycobacterium tuberculosis, Receptors, Cell Surface, Th2 Cells, Transfection},
  author = {Soilleux E J and Sarno E N and Hernandez M O and Moseley E and Horsley J and Lopes U G and Goddard M J and Vowler S L and Coleman N and Shattock R J and Sampaio E P},
  title = {DC-SIGN association with the Th2 environment of lepromatous lesions: cause or effect?},
  abstract = {<p>The clinical spectrum of leprosy is related to patients' immune responses. Non-responsiveness towards Mycobacterium leprae (ML) seems to correlate with a Th2 cytokine profile. The reason for such a polarized immune response remains unclear. The C-type lectin, DC-SIGN, expressed by subsets of dendritic cells (DCs) and macrophages, has previously been associated with Th2 responses. Here we show abundant DC-SIGN expression in lepromatous but not borderline tuberculoid leprosy, in both HIV-positive and HIV-negative patients. Moreover, we demonstrate that DC-SIGN can act as an entry receptor for ML, as it does for M. tuberculosis, through the cell wall component lipoarabinomannan. DC-SIGN is expressed on virtually all ML-containing cells, providing further evidence for its role as a receptor. DC-SIGN may therefore be induced on macrophages in lepromatous leprosy and may then contribute to mycobacterial entry into these cells.</p>},
  year = {2006},
  journal = {The Journal of pathology},
  volume = {209},
  pages = {182-9},
  month = {2006 Jun},
  issn = {0022-3417},
  doi = {10.1002/path.1972},
  language = {eng},
}