@article{6861,
  keywords = {Concanavalin A, Erythema Nodosum, Humans, leprosy, Lymphocyte Activation, Mitogens, Mitomycins, Mycobacterium Infections, Nontuberculous, Mycobacterium leprae, T-Lymphocytes, Regulatory},
  author = {Nath I and Narayanan R B and Mehra N K and Sharma A K and Gupte M D},
  title = {Concanavalin A induced suppressor activity in human leprosy.},
  abstract = {<p>Peripheral blood lymphocytes from nine normal subjects and 40 patients with leprosy were pretreated in vitro with Concanavalin A (Con A). Cells from normal subjects pretreated for 24 hours showed consistent and effective generation of suppressive activity which inhibited mitogen induced transformation of autologous lymphocytes. Prolongation of Con A pretreatment to 40 hours resulted in maximal suppressive activity. Tuberculoid leprosy patients had lymphocytes in their blood which on 24 hour pretreatment with Con A exerted suppressive effects markedly greater than the maximal suppression noted with 40 hour pretreated normal lymphocytes. In contrast, untreated patients with polar lepromatous leprosy showed a decrease in suppressive activity which could not be altered by prolongation of Con A pretreatment: the loss of suppressive activity noted in this form of leprosy was restored during erythema nodosum leprosum.</p>},
  year = {1979},
  journal = {Journal of clinical & laboratory immunology},
  volume = {2},
  pages = {319-24},
  month = {1979 Nov},
  issn = {0141-2760},
  language = {eng},
}