@article{684,
  keywords = {Adolescent, Adult, BCG Vaccine, Case-Control Studies, Chi-Square Distribution, Child, Confidence Intervals, Female, Humans, India, leprosy, Male, Matched-Pair Analysis, Odds Ratio, Social Class},
  author = {Kulkarni H R and Zodpey S P},
  title = {Differential protective effect of bacillus Calmette-Guerin vaccine against multibacillary and paucibacillary leprosy in Nagpur, India.},
  abstract = {<p>For this paper we conducted a secondary data analysis to test the hypothesis that a linear trend exists in the protective effect of bacillus Calmette-Guerin (BCG) vaccine against types of leprosy. We used data from two previous case-control studies to perform an unmatched test for linear trend. We observed that both the studies revealed a significant linear trend (P<0.00001). One study that estimated an insignificant protective effect of BCG against paucibacillary leprosy showed a significant departure from linearity. We conclude that, the protective effect of BCG vaccination is differential across severity of leprosy as it brings about a shift in the immune response to a higher level of cell mediated immunity. We recommend that future studies dealing with the protective effect of BCG against leprosy should also conduct an analysis for trend.</p>},
  year = {1999},
  journal = {Public health},
  volume = {113},
  pages = {311-3},
  month = {1999 Nov},
  issn = {0033-3506},
  doi = {10.1016/s0033-3506(99)00187-0},
  language = {eng},
}