@article{6788,
  keywords = {Brazil, Case-Control Studies, DNA Mutational Analysis, Female, Genetic Markers, Humans, Immunity, Innate, Indians, South American, Interleukin-10, leprosy, Male, polymerase chain reaction, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Quantitative Trait Loci},
  author = {Malhotra D and Darvishi K and Sood S and Sharma S and Grover C and Relhan V and Reddy B S N and Bamezai R N K},
  title = {IL-10 promoter single nucleotide polymorphisms are significantly associated with resistance to leprosy.},
  abstract = {<p>The minor haplotype -3575A/-2849G/-2763C in IL-10 promoter has been defined as a marker of disease resistance to leprosy and its severity in Brazilian population. Our investigation of six single-nucleotide polymorphisms (SNPs) in IL-10 promoter in 282 Indian leprosy patients and 266 healthy controls by direct PCR sequencing, however, showed that the extended haplotype: -3575T/-2849G/-2763C/-1082A/-819C/-592C was associated with resistance to leprosy per se and to the development of severe form of leprosy, using either a binomial (controls vs cases, P=0.01, OR=0.58, CI=0.37-0.89) or ordinal (controls vs paucibacillary vs multibacillary, P=0.004) model. Whereas, IL-10 haplotype -3575T/-2849G/-2763C/-1082A/-819T/-592A was associated with the risk of development of severe form of leprosy (P=0.0002) in contrast to the minor risk haplotype -3575T/-2849A/-2763C in the Brazilian population. The role of IL-10 promoter SNPs in Brazilian and Indian population strongly suggests the involvement of IL-10 locus in the outcome of leprosy.</p>},
  year = {2005},
  journal = {Human genetics},
  volume = {118},
  pages = {295-300},
  month = {2005 Nov},
  issn = {0340-6717},
  doi = {10.1007/s00439-005-0042-8},
  language = {eng},
}