@article{6650,
  keywords = {Animals, B-Lymphocytes, Cell Count, Female, Immunoglobulins, leprosy, Leukocyte Count, Mice, Mice, SCID, Severe Combined Immunodeficiency, Spleen, T-Lymphocytes},
  author = {Xabier M G and Howe R C and Frommel D},
  title = {[Infection and elimination of Mycobacterium leprae in SCID C.B.-17 mice (severe combined immunodeficiency)].},
  abstract = {<p>Previous studies documented that T-cell deficient nude mice failed to control M. leprae infection. In the present investigation we monitored the growth of M. leprae for up to 15 months in the SCID C.B.-17 mouse, a host deficient in both T and B lymphocytes. At 8 months post-infection 10(8) organisms/foot-pad were recovered from SCID mice vs 5 x 10(6) in normal BALB/c mice. Thereafter the number of bacilli decreased rapidly in mice infected with high-dose inoculum (10(7)); however, at all doses SCID mice eventually cleared M. leprae. During infection both T and B cells as well as serum Ig remained as low as in uninfected mice; however, in the spleen MAC-1+ cells which include macrophages and NK cells were substantially increased. These results suggest that MAC-1+ cells are involved in the anti-mycobacteria-1 defence mechanisms adopted by SCID mice to compensate their deficiency in T and B cells.</p>},
  year = {1992},
  journal = {Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie},
  volume = {314},
  pages = {99-103},
  month = {1992},
  issn = {0764-4469},
  language = {fre},
}