@article{6578,
  keywords = {Arthritis, Cicatrix, Clofazimine, Dose-Response Relationship, Drug, Drug-Related Side Effects and Adverse Reactions, Edema, Erythema, Erythema Nodosum, Foot, Glucocorticoids, Hand, Humans, Hypersensitivity, Immunosuppressive Agents, leprosy, Lymphadenitis, Neuritis, Paralysis, Prednisolone, Skin, Thalidomide, Treatment Outcome},
  author = {Ganapati R and Pai V V},
  title = {Reactions and their management.},
  abstract = {<p>The uneventful response to chemotherapy in leprosy is marked by clinically disturbing episodes encountered in 20-30% of patients and these phenomena are called "reactions". Generally they are classified as reversal reaction (type-1) and erythema nodosum leprosum (type-2). The cutaneous menifestations are: (1) Type-2 reactions in LL, BL types constituting erythema nodosum leprosum, erythema multiforme, erythema necroticans, subcutaneous nodules, lepromatous exacerbation. (2) Type-1 reactions in borderline and tuberculoid leprosy. The other manifestations include: Acute neuritis, lymphadenitis, arthritis, oedema of the hands and feet, ocular lesions, etc. Sequelae of reactions are: Paralytic deformities, non-paralytic deformities, extensive scarring and renal damage. A simple guideline to identify the risk-prone cases has been narrated. Prednisolone in standard dosage schedule as recommended by WHO is now being widely used in control programmes.</p>},
  year = {2004},
  journal = {Journal of the Indian Medical Association},
  volume = {102},
  pages = {688-90, 692, 694},
  month = {2004 Dec},
  issn = {0019-5847},
  language = {eng},
}