@article{6551,
  keywords = {Clofazimine, Dapsone, Drug Therapy, Combination, Ethionamide, Humans, Leprostatic Agents, leprosy},
  author = {Pattyn S R and Bourland J},
  title = {Ambulatory treatment of multibacillary leprosy with a regimen of 8 months duration.},
  abstract = {<p>An ambulatory treatment regimen for multibacillary leprosy, of 34 weeks duration composed of 8 weeks daily supervised rifampicin, ethionamide (ETH), dapsone (DDS) and clofazimine (CLO) followed by 26 weeks of unsupervised ETH, DDS and CLO, introduced in 1983 has been evaluated; 268 patients were followed for a mean of 4.4 years and a total of 1188 patient years. The relapse rate was 0.33 per 100 patient years of follow up. The reduction of the duration of the combined administration of RMP + ETH reduced the hepatotoxicity to 1.4%. It is possible that both phases of the regimen studied could still be reduced, however, in the near future ETH will be replaced by alternative bactericidal drugs, avoiding the hepatotoxicity.</p>},
  year = {1992},
  journal = {Leprosy review},
  volume = {63},
  pages = {36-40},
  month = {1992 Mar},
  issn = {0305-7518},
  url = {http://leprev.ilsl.br/pdfs/1992/v63n1/pdf/v63n1a06.pdf},
  doi = {10.5935/0305-7518.19920006},
  language = {eng},
}