@article{6403, keywords = {Antigen Presentation, Cytokines, Humans, leprosy, Macrophages, Mycobacterium leprae, Phagocytosis}, author = {Fukutomi Y}, title = {[Functional changes of macrophages in Hansen's disease].}, abstract = {

As an obligate intracellular pathogen, the principal host cells for Mycobacterium leprae are mononuclear phagocytes or macrophages. The macrophage is a primitive cell type being found in both early and advanced life forms, and possesses a variety of functions, such as phagocytosis of invaded bacteria, production of cytokines, antigen presentation and tumor killing. Hansen's disease is a chronic infectious disease characterized by specific host immune responses against M. leprae. In this article the macrophage is focused to dissect its functions in the disease.

}, year = {2004}, journal = {Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association}, volume = {73}, pages = {253-61}, month = {2004 Sep}, issn = {1342-3681}, language = {jpn}, }