@article{6367,
  keywords = {Antigens, CD, Case-Control Studies, Glycoproteins, Humans, Immunoglobulins, Interferon-gamma, leprosy, Leprosy, Tuberculoid, Receptors, Cell Surface, RNA, Messenger, Signaling Lymphocytic Activation Molecule Family Member 1, Th1 Cells, Th2 Cells},
  author = {Quiroga MF and Martínez G and Pasquinelli V and García VE},
  title = {[The SLAM-associated protein (SAP) regulates IFN-gamma expression in leprosy].},
  abstract = {<p>The SLAM-associated protein (SAP) regulates IFN-gamma expression in leprosy. Tuberculoid leprosy patients locally produce Th1 cytokines, while lepromatous patients produce Th2 cytokines. Signaling lymphocytic activation molecule (SLAM) and the SLAM-associated protein (SAP) participate in the differentiation process that leads to the production of specific patterns of cytokines by activated T cells. To investigate the SLAM/SAP pathway in M. leprae infection, we determined the expression of SAP, IFN-gamma and SLAM RNA messenger in leprosy patients. We found a direct correlation of SLAM expression with IFN-gamma expression, whereas the expression of SAP was inversely correlated with the expression of both SLAM and IFN-gamma. Therefore, our data indicate that SAP might interfere with Th1 cytokine responses while SLAM expression may contribute to Th1 responses in leprosy. This study further suggests that the SLAM/SAP pathway might be a focal point for therapeutic modulation of T cell cytokine responses in diseases characterized by dysfunctional Th2 responses.</p>},
  year = {2004},
  journal = {Medicina},
  volume = {64},
  pages = {436-8},
  month = {2004},
  issn = {0025-7680},
  language = {spa},
}