@article{6319,
  keywords = {Animals, Humans, Immune Tolerance, leprosy, Lymphokines, T-Lymphocytes, Regulatory},
  author = {Bloom B R and Modlin R L and Salgame P},
  title = {Stigma variations: observations on suppressor T cells and leprosy.},
  abstract = {<p>Few areas of immunology have been so controversial as that of suppressor T cells. Studies of T cell clones derived from patients with infectious diseases, including leprosy, and allergies have allowed the delineation of functional human T cell subsets. Both CD4 and CD8 cells can be discriminated into subsets that are differentiated by their functions and patterns of lymphokines. Type 1 CD4 cells reactive with lepromin and PPD produce IFN-gamma and IL-2 predominantly, while Type 2 CD4 clones, specific for tetanus toxoid, produce IL-4 and IL-5. Type 1 CD8 cytotoxic T lymphocytes produce predominantly IFN-gamma and IL-2. T suppressor clones derived from immunologically unresponsive lepromatous leprosy patients are antigen-specific, CD8 cells, HLA-DQ restricted, and produce predominantly IL-4, and were designated Type 2 CD8 cells. Several models for peripheral tolerance based on distinct functional T cell subsets are discussed. Previous models of T cell suppression in the mouse and the reciprocal relationship between humoral and cell-mediated immunity in general are reinterpreted in light of such T cell subset interactions.</p>},
  year = {1992},
  journal = {Annual review of immunology},
  volume = {10},
  pages = {453-88},
  month = {1992},
  issn = {0732-0582},
  doi = {10.1146/annurev.iy.10.040192.002321},
  language = {eng},
}