@article{6315,
  keywords = {Cell Line, Cytokines, Humans, leprosy, Leukocyte Count, Lymphocyte Activation, Mycobacterium tuberculosis, T-Lymphocytes, Tuberculin Test, Tuberculosis, Miliary, Tuberculosis, Pleural, Tuberculosis, Pulmonary},
  author = {Barnes P F and Grisso C L and Abrams J S and Band H and Rea T H and Modlin R L},
  title = {Gamma delta T lymphocytes in human tuberculosis.},
  abstract = {<p>The manifestations of tuberculous infection reflect the immune response to infection. Most healthy tuberculin reactors develop protective immunity; tuberculous pleuritis reflects a resistant response manifest by mild disease, whereas advanced pulmonary and miliary tuberculosis reflect ineffective immunity. The role of gamma delta T cells was assessed in tuberculous infection by evaluating expansion of these cells from blood mononuclear cells after stimulation with Mycobacterium tuberculosis. After culture in vitro, the percentages of gamma delta+ cells were significantly greater in patients with protective and resistant immunity (tuberculin reactors, 25% +/- 4%; tuberculous pleuritis, 30% +/- 7%) than in those with ineffective immunity (advanced pulmonary tuberculosis, 9% +/- 3%; miliary tuberculosis, 2% +/- 1%). In leprosy, expansion of gamma delta+ cells was greater in immunologically resistant tuberculoid patients (32% +/- 4%) than in Mycobacterium leprae-unresponsive lepromatous patients (9% +/- 2%). M. tuberculosis-reactive gamma delta T cell lines produced interferon-gamma, granulocyte-macrophage colony-stimulating factor, interleukin-3, and tumor necrosis factor-alpha, cytokines that activate macrophages and may contribute to mycobacterial elimination. These findings suggest that gamma delta T cells contribute to immune resistance against M. tuberculosis.</p>},
  year = {1992},
  journal = {The Journal of infectious diseases},
  volume = {165},
  pages = {506-12},
  month = {1992 Mar},
  issn = {0022-1899},
  doi = {10.1093/infdis/165.3.506},
  language = {eng},
}