@article{6292,
  keywords = {Confidence Intervals, Female, Gene Frequency, Genetic Markers, Genetic Predisposition to Disease, Haplotypes, Humans, Interleukin-10, leprosy, Logistic Models, Male, Odds Ratio, Polymorphism, Single Nucleotide, Promoter Regions, Genetic},
  author = {Moraes M O and Pacheco A G and Schonkeren J J M and Vanderborght P R and Nery J A C and Santos A R and Moraes M E and Moraes J R and Ottenhoff T H M and Sampaio E P and Huizinga T W J and Sarno E N},
  title = {Interleukin-10 promoter single-nucleotide polymorphisms as markers for disease susceptibility and disease severity in leprosy.},
  abstract = {<p>We have determined IL-10 promoter genotypes of five single-nucleotide polymorphisms (SNPs): T-3575A, A-2849G, C-2763A, -A-1082G and C-819T. The haplotype frequencies were defined in healthy subjects compared to leprosy patients, and analyzed for their occurrence in multi- (MB) vs paucibacillary (PB) as severe and mild forms of leprosy, respectively. Haplotypes defined by three SNP positions (-3575, -2849 and -2763) captured significant differences between controls and patients (P=0.04). The haplotype carrying -3575A, -2849G and -2763C was associated with resistance to leprosy and to the development of severe forms of the disease using either a binomial (controls vs cases, P=0.005, OR=0.35, CI=0.13-0.91) or ordinal (controls vs PB vs MB, P=0.006, OR=0.32, CI=0.12-0.83) model. By contrast, the IL-10 haplotype -3575T/-2849A/-2763C was found to be associated with susceptibility to leprosy per se (P=0.027, OR=2.37, CI=1.04-5.39), but not leprosy type. The data suggest that the IL-10 locus contributes to the outcome of leprosy.</p>},
  year = {2004},
  journal = {Genes and immunity},
  volume = {5},
  pages = {592-5},
  month = {2004 Nov},
  issn = {1466-4879},
  url = {http://www.nature.com/gene/journal/v5/n7/pdf/6364122a.pdf},
  doi = {10.1038/sj.gene.6364122},
  language = {eng},
}