@article{6291,
  keywords = {AIDS-Related Opportunistic Infections, Anti-HIV Agents, Autoimmune Diseases, Diagnosis, Differential, Female, HIV Infections, Humans, Leprostatic Agents, leprosy, Male, Middle Aged},
  author = {Couppié P and Abel S and Voinchet H and Roussel M and Hélénon R and Huerre M and Sainte-Marie D and Cabié A},
  title = {Immune reconstitution inflammatory syndrome associated with HIV and leprosy.},
  abstract = {<p><b>BACKGROUND: </b>Immune reconstitution inflammatory syndrome (IRIS) is an unusual inflammatory reaction to an opportunistic infection that occurs in human immunodeficiency virus (HIV)-positive patients with profound immunosuppression during the reconstitution of the immune system in the initial months of highly active antiretroviral treatment.</p><p><b>OBSERVATIONS: </b>We describe 3 cases of leprosy occurring in patients treated with a combination of 3 antiretroviral drugs who fulfilled the criteria for IRIS. A reactional state occurred in all 3 cases. Two of the 3 patients presented an unusual ulcerous progression of the lesions not generally observed in cases of leprosy. The outcome was favorable in all 3 cases. The frequency of IRIS associated with leprosy in French Guiana and Martinique is estimated at 3 cases per 1000 HIV-positive patients receiving highly active antiretroviral treatment.</p><p><b>CONCLUSION: </b>Leprosy should be recognized as an IRIS-associated infection with possibility of atypical presentation.</p>},
  year = {2004},
  journal = {Archives of dermatology},
  volume = {140},
  pages = {997-1000},
  month = {2004 Aug},
  issn = {0003-987X},
  doi = {10.1001/archderm.140.8.997},
  language = {eng},
}