@article{6268,
  keywords = {Adolescent, Adult, Aged, Case-Control Studies, Genetic Predisposition to Disease, genotype, Humans, leprosy, Malawi, Middle Aged, Polymorphism, Genetic, Sequence Analysis, DNA},
  author = {Fitness J and Floyd S and Warndorff DK and Sichali L and Mwaungulu L and Crampin AC and Fine PE and Hill A},
  title = {Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi.},
  abstract = {<p>We present a large case-control candidate gene study of leprosy susceptibility. Thirty-eight polymorphic sites from 13 genes were investigated for their role in susceptibility to leprosy by comparing 270 cases with 452 controls in Karonga district, northern Malawi. Homozygotes for a silent T-->C change in codon 352 of the vitamin D receptor gene appeared to be at high risk (odds ratio [OR] = 4.3, 95% confidence interval [CI] = 1.6-11.4, P = 0.004), while homozygotes for the McCoy b blood group defining variant K1590E in exon 29 of the complement receptor 1 (formerly CD35) gene appeared to be protected (OR = 0.3, 95% CI = 0.1-0.8, P = 0.02). Borderline evidence for association with leprosy susceptibility was found for seven polymorphic sites in an additional six genes. Some of these apparent associations may be false-positive results from multiple comparisons, and several associations suggested by studies in other populations were not replicated here. These data provide evidence of inter-population heterogeneity in leprosy susceptibility.</p>},
  year = {2004},
  journal = {The American journal of tropical medicine and hygiene},
  volume = {71},
  pages = {330-40},
  month = {2004 Sep},
  issn = {0002-9637},
  url = {http://www.ajtmh.org/content/71/3/330.full.pdf},
  language = {eng},
}