@article{6136,
  keywords = {Antigen Presentation, Antigens, CD, Antigens, CD1, Antigens, Surface, Cell Division, Dose-Response Relationship, Drug, Epidermis, Fetal Blood, Humans, Immunohistochemistry, Langerhans Cells, Lectins, Lectins, C-Type, leprosy, Mannose-Binding Lectins, Microscopy, Fluorescence, Mycobacterium leprae, Phenotype, Receptors, Antigen, T-Lymphocytes},
  author = {Hunger R and Sieling PA and Ochoa MT and Sugaya M and Burdick A and Rea T and Brennan PJ and Belisle JT and Blauvelt A and Porcelli SA and Modlin RL},
  title = {Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.},
  abstract = {<p>Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in a CD1a-restricted and langerin-dependent manner. LC-like DCs were more efficient at CD1a-restricted antigen presentation than monocyte-derived DCs. LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease.</p>},
  year = {2004},
  journal = {The Journal of clinical investigation},
  volume = {113},
  pages = {701-8},
  month = {2004 Mar},
  issn = {0021-9738},
  doi = {10.1172/JCI19655},
  language = {eng},
}