@article{5585,
  keywords = {Amino Acid Sequence, Animals, Antigens, Bacterial, Bacterial Proteins, Cross Reactions, Humans, Interferon-gamma, leprosy, Lymphocyte Activation, Molecular Sequence Data, Mycobacterium leprae, Mycobacterium tuberculosis, Sequence Homology, T-Lymphocytes, Tuberculosis},
  author = {Geluk A and Meijgaarden K E and Franken K L M C and Wieles B and Arend S M and Faber W R and Naafs B and Ottenhoff T H M},
  title = {Immunological crossreactivity of the Mycobacterium leprae CFP-10 with its homologue in Mycobacterium tuberculosis.},
  abstract = {<p>Mycobacterium tuberculosis culture filtrate protein-10 (CFP-10) (Rv3874) is considered a promising antigen for the immunodiagnosis of tuberculosis (TB) together with early secreted antigens of M. tuberculosis (ESAT-6). Both ESAT-6 and CFP-10 are encoded by the RD1 region that is deleted from all tested M. bovis bacille Calmette-Guérin (BCG) strains but present in M. leprae, M. tuberculosis, M. bovis, M. kansasii, M. africanum and M. marinum. In this study, the homologue of CFP-10 in M. leprae (ML0050) is identified and characterized. Interferon-gamma production in response to this homologue by T cells from leprosy patients, TB patients and unexposed controls shows that CFP-10 of M. leprae is a potent antigen that crossreacts with CFP-10 of M. tuberculosis at the T-cell level. This crossreactivity has implications for the use of CFP-10 of these mycobacterial species as diagnostic tool in areas endemic for both the diseases.</p>},
  year = {2004},
  journal = {Scandinavian journal of immunology},
  volume = {59},
  pages = {66-70},
  month = {2004 Jan},
  issn = {0300-9475},
  doi = {10.1111/j.0300-9475.2004.01358.x},
  language = {eng},
}