@article{5521,
  keywords = {Acetylglucosaminidase, Adult, Cross-Sectional Studies, Drug Synergism, Drug Therapy, Combination, Glomerular Filtration Rate, Humans, Kidney, leprosy, Middle Aged, Prospective Studies, Rifampin, Streptomycin, Tuberculosis, Pulmonary},
  author = {Kumar B D and Prasad C E and Krishnaswamy K},
  title = {Detection of rifampicin-induced nephrotoxicity by N-acetyl-3-D-glucosaminidase activity.},
  abstract = {<p>The objective of the present study was to assess renal damage, if any, by non-invasive technique, viz NAG activity in urine and GFR in patients on continuous and intermittent rifampicin therapy. Eighty-four tuberculosis patients for cross-sectional study and six subjects for longitudinal study on antitubercular therapy and ten patients on withdrawal of rifampicin participated in the investigation; 13 leprosy patients intermittently treated with rifampicin were also included. Twenty-seven normal subjects served as controls. Rifampicin on continuous use resulted in a progressive increase in enzymuria with no change in GFR. An additive toxic effect was obvious in patients receiving streptomycin; when the treatment was withdrawn the urinary NAG activity stabilized within 15-21 days. However, patients receiving rifampicin intermittently did not show any evidence of renal damage. The results suggest that there is a need for monitoring renal damage, particularly on antitubercular therapy, when nephrotoxic agents are administered together.</p>},
  year = {1992},
  journal = {The Journal of tropical medicine and hygiene},
  volume = {95},
  pages = {424-7},
  month = {1992 Dec},
  issn = {0022-5304},
  language = {eng},
}