@article{5391,
  keywords = {Aniline Compounds, Animals, Biochemical Phenomena, Dapsone, Guinea Pigs, leprosy, Oxidation-Reduction, Rabbits, Rats, Safrole, Sulfones, Sulfoxides, Sulfur},
  author = {LEVI A A and SNOW G A},
  title = {Metabolism and excretion of di(p-aminophenyl) sulphoxide in different animal species.},
  abstract = {<p>Rabbits, rats and guinea-pigs were treated with di(p-aminophenyl) sulphoxide and their urines examined by an analytical method which permits the simultaneous determination of this compound and of dapsone [di(p-aminophenyl) sulphone] which is a possible product of metabolic oxidation. The method gives for each drug the total of free compound plus acid-labile conjugates. All three species excreted unchanged drug together with dapsone. With rats and guinea-pigs about 33% of the excretion is dapsone, but with rabbits only 6 to 12%. The rate of combined excretion is much greater in rabbits than in the other two species. These results are discussed in relation to the significance of di(p-aminophenyl) sulphoxide as a drug in the treatment of leprosy.</p>},
  year = {1960},
  journal = {British journal of pharmacology and chemotherapy},
  volume = {15},
  pages = {160-4},
  month = {1960 Mar},
  issn = {0366-0826},
  doi = {10.1111/j.1476-5381.1960.tb01225.x},
  language = {eng},
}