@article{5264,
  keywords = {Adult, Aged, Biopsy, Drug Administration Schedule, Female, Humans, Injections, Intralesional, Interferon-gamma, Leprosy, lepromatous, Male, Middle Aged, Recombinant Proteins, Skin, Time Factors},
  author = {Bottasso O and Besuschio S and Merlin V and Morini J C and Bernabo J and Falcoff R and Falcoff E},
  title = {Lepromatous leprosy treated with recombinant interferon gamma: cutaneous histologic changes.},
  abstract = {<p>We report on the histologic changes occurring in single cutaneous lesions, from six active lepromatous patients, 1 week following the administration of three daily intradermal injections, 35 micrograms each, of recombinant interferon gamma (rIFN-gamma). Except for a strong induration at the injection site, rIFN-gamma produced no adverse systemic reactions and was able to promote a remarkable influx of T-lymphocytes, mononuclear phagocytes with large nuclei, nonvacuolated cytoplasm, and reduced lysozyme reactivity. Furthermore, despite no clear-cut reduction of mycobacterial dermal burden, bacilli showed a clear increase in the granular appearance. Present findings provide a basis for further elucidation of rIFN-gamma as an additional tool for leprosy treatment.</p>},
  year = {1992},
  journal = {International journal of dermatology},
  volume = {31},
  pages = {813-7},
  month = {1992 Nov},
  issn = {0011-9059},
  doi = {10.1111/j.1365-4362.1992.tb04253.x},
  language = {eng},
}