@article{3865,
  keywords = {Animals, Anti-Infective Agents, Female, Fluoroquinolones, Foot, Mice, Mice, Inbred BALB C, Mice, Nude, Mycobacterium leprae, Quinolones},
  author = {Gidoh M and Tsutsumi S},
  title = {Activity of sparfloxacin against Mycobacterium leprae inoculated into footpads of nude mice.},
  abstract = {<p>The antileprosy activity of a new quinolone, sparfloxacin, was examined in the nude mouse footpad model. By serial dosing (once a day, 5 or 6 times per week, during the 3rd-5th months postinoculation), 10 mg/kg of sparfloxacin displayed bactericidal-type activity and bacteriostatic activity was present at daily doses of 5 and 2 mg/kg. By intermittent dosing (once a day, twice weekly at daily doses of 10 and 20 mg/kg or once weekly at a daily dose of 30 mg/kg, during the 3rd-5th months postinoculation), sparfloxacin markedly inhibited the growth of leprosy bacilli with slight remultiplication at later stages. Sparfloxacin seems to be worth studying clinically as a novel antileprosy drug.</p>},
  year = {1992},
  journal = {Leprosy review},
  volume = {63},
  pages = {108-16},
  month = {1992 Jun},
  issn = {0305-7518},
  url = {http://leprev.ilsl.br/pdfs/1992/v63n2/pdf/v63n2a03.pdf},
  language = {eng},
}