@article{33695,
  author = {Kama G and Huang G K L and Taune M and Arura R and Morris L and Kombuk B and Marome A and O'Brien D P},
  title = {Tuberculosis treatment unmasking leprosy: management of drug-resistant tuberculosis and leprosy co-infection.},
  abstract = {<p>Co-infection with tuberculosis (TB) and leprosy is thought to occur infrequently, but has been reported in settings highly endemic for both infectious diseases. We report for the first time a case where treatment for multidrug-resistant TB (MDR-TB) led to the 'unmasking' of clinically silent leprosy through the precipitation of a type-1 immunological reaction. Current treatment regimens for MDR-TB may contain a number of drugs, such as levo-floxacin and clofazimine, which also have activity against M. leprae. A treatment regimen containing drugs active against both mycobacterial species may be used to achieve cure. Individual considerations on drug-drug interactions, potential additive toxicities and other comorbidities should be taken into account.</p>
},
  year = {2019},
  journal = {Public health action},
  volume = {9},
  pages = {S83-S85},
  issn = {2220-8372},
  doi = {10.5588/pha.18.0104},
  language = {eng},
}