@article{3348,
  keywords = {Benzamides, Cells, Cultured, Chromosome Aberrations, DNA Repair, Humans, leprosy, Lymphocytes, Male, Poly Adenosine Diphosphate Ribose, Poly(ADP-ribose) Polymerase Inhibitors, Sister Chromatid Exchange},
  author = {D'Souza D and Thomas I M and Das B C},
  title = {Effect of inhibitor of poly (ADP-ribose) polymerase in blood lymphocyte cultures of untreated leprosy patients.},
  abstract = {<p>Poly (ADP-ribose) polymerase is a cellular repair enzyme synthesised following damage to DNA. 3-Aminobenzamide (3-AB) is an inhibitor of this repair enzyme. To study repair efficiency in leprosy patients, who usually show a significantly higher frequency of spontaneous chromosome aberrations and sister-chromatid exchanges (SCEs), their blood lymphocyte cultures were treated with 3-AB. A marginal increase in the frequency of chromosome aberrations was observed following treatment with 3-AB in controls as well as in patient groups. There was also no significant difference in the frequency of SCEs in control cultures with or without 3-AB. A significant increase in the frequency of SCEs was observed in lymphocyte cultures of paucibacillary (PB) and multibacillary (MB) patients treated with 3-AB when compared with controls. Observation of a significant increase in the frequency of SCEs in 3-AB-treated cultures over the untreated value indicates that DNA damage caused in leprosy patients following mycobacterial infection is not repaired because of the presence of the inhibitor of repair enzyme.</p>},
  year = {1992},
  journal = {Mutation research},
  volume = {284},
  pages = {251-5},
  month = {1992 Dec 16},
  issn = {0027-5107},
  doi = {10.1016/0027-5107(92)90009-q},
  language = {eng},
}