@article{32529,
  keywords = {leprosy, Clinico-histological, Correlation, Fite-faraco, Hansen{\textquoteright}s disease, India},
  author = {Semwal S and Joshi D and Goel G and Asati D and Kapoor N},
  title = {Clinico-histological correlation in Hansen{\textquoteright}s disease: Three-year experience at a newly established tertiary care center in central India.},
  abstract = {<p><strong>Background:</strong> Hansen{\textquoteright}s disease is a chronic infectious disease caused by <em>Mycobacterium leprae.</em> It is characterized by a wide range of clinical and histological manifestations. Ridley{\textendash}Jopling criteria are widely used for classifying leprosy. The demonstration of acid-fast bacilli on slit-skin smear examination and in skin biopsy aids in its diagnosis. <strong>Aim:</strong> The aim of the present study was to perform clinico-histological correlation of skin lesions in all patients with a clinical suspicion of Hansen{\textquoteright}s disease. <strong>Materials and Methods:</strong> The study included skin biopsies of all suspected cases of Hansen{\textquoteright}s disease received over a period of 3 years. Hematoxylin and eosin and Fite-Faraco stained sections of all cases were examined. Corresponding slit-skin smears, if available, were also reviewed. <strong>Results:</strong> During the study, a total of 116 cases were clinically diagnosed as Hansen{\textquoteright}s disease. Clinico-histological correlation was obtained in 62.9\% of the cases (73/116). The most common histological subtype of Hansen{\textquoteright}s disease was borderline tuberculoid (TT) (40/116). Seven cases were diagnosed as lepromatous leprosy, five as TT, four as histoid, one as indeterminate, and three cases diagnosed as erythema nodosum leprosum. Fite-Faraco stain was positive in 33/73 cases. Out of 116 cases, slit-skin smears were available for 43 cases and were positive in 23 cases. <strong>Conclusion:</strong> Correlation between clinical, bacteriological, and morphological features is required for accurate classification of Hansen{\textquoteright}s disease. Clinical detection and morphological diagnosis of early lesions remain challenging, and the histological findings should always be interpreted in correlation with clinical findings.</p>
},
  year = {2018},
  journal = {Indian journal of dermatology},
  volume = {63},
  pages = {465-468},
  url = {http://www.e-ijd.org/article.asp?issn=0019-5154;year=2018;volume=63;issue=6;spage=465;epage=468;aulast=Semwal},
  language = {eng},
}