@article{3123, keywords = {Drug Therapy, Combination, Erythema Nodosum, Humans, Incidence, Leprostatic Agents, leprosy, Leprosy, lepromatous, Models, Molecular, Mycobacterium leprae, Thalidomide, Tumor Necrosis Factor-alpha}, author = {Teo SK and Resztak K and Scheffler MA and Kook KA and Zeldis JB and Stirling DI and Thomas S}, title = {Thalidomide in the treatment of leprosy.}, abstract = {

Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflammatory cytokine TNF-alpha produced by monocytes.

}, year = {2002}, journal = {Microbes and infection}, volume = {4}, pages = {1193-202}, month = {2002 Sep}, issn = {1286-4579}, language = {eng}, }