@article{30938,
  keywords = {NF-κB, MAP3K14, M. Leprea, leprosy, FMNL1},
  author = {Zhang H and Wang Z and Fu X and Sun Y and Mi Z and Yu G and Sun L and Wang N and Wang C and Zhao Q and Pan Q and Yue Z and Liu H and Zhang F},
  title = {A pathway-based association analysis identified FMNL1-MAP3K14 as susceptibility genes for leprosy.},
  abstract = {<p>The nuclear transcription factor-κB (NF-κB) plays a pivotal role in controlling both innate and adaptive immunity and regulates the expressions of many immunological mediators. Abundant evidences have showed that the importance of NF-κB pathway in the host immune responses against Mycobacterium leprae in the development of leprosy. However, no particular association study between leprosy and NF-κB pathway related gene polymorphisms was reported. Here, we performed a large scale and two-stage candidate association study to investigate the association between 94 NF-κB pathway related genes and leprosy. Our results showed that rs58744688 was significantly associated with leprosy (P=7.57×10-7 , OR=1.12) by combining the previous genome wide association datasets and four independent validation sample series, consisting of a total of 4631 leprosy cases and 6413 healthy controls. This founding implicated that MAP3K14 and FMNL1 were susceptibility genes for leprosy, which suggested the involvement of macrophage targeting and NF-κB pathway in the development of leprosy. This article is protected by copyright. All rights reserved.</p>
},
  year = {2017},
  journal = {Experimental dermatology},
  issn = {1600-0625},
  doi = {10.1111/exd.13490},
  language = {eng},
}