@article{30731,
  keywords = {Performance status, leprosy, Gene polymorphism, CTLA-4, Age at the disease onset},
  author = {Almasi S and Aliparasti MR and Naghili B and Yeganeh K and Tavanafar F and Amini-Khiabani S and Babaloo Z},
  title = {Analysis of CTLA-4+49A/G gene polymorphism in cases with leprosy of Azerbaijan, Northwest Iran.},
  abstract = {<p>Leprosy, which is developed by the obligate intracellular Mycobacterium leprae (ML); has different manifestations, associated with the host immune responses. The protective immune response against ML includes T-cell-mediated immunity. The CTLA-4 has a great impact as a negative regulator of the immune response and maintenance of peripheral tolerance. This study analyzed the relationship between CTLA-4+49A/G gene polymorphism and clinical manifestation of leprosy disease and susceptibility among the Azeri population living Northwest Iran. One hundred and fifty- six leprosy patients and 185 healthy controls participated in the study. CTLA-4+49A/G genotyping was conducted via tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) analysis. The allelic and genotypic frequencies of +49A/G gene polymorphism were similar in controls and patients. However older age of onset and over-representation in male were observed in leprosy patient carriers of GG genotype. The current study demonstrates that although CTLA-4+49A/G polymorphism was not correlated with a higher genetic risk for leprosy, the presence of a GG genotype was associated with a older age of onset and over-representation in male in Iranian Azeri population.</p>
},
  year = {2018},
  journal = {Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  pages = {121-127},
  issn = {1567-7257},
  doi = {10.1016/j.meegid.2017.11.001},
  language = {eng},
}